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Publikationen zu seltenen Nierenerkrankungen

  • Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O,Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G,Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney DiseaseCandidate Genes. Cell Rep. 2018 May 22;23(8):2495-2508.
  • Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 Jun;93(6):1298-1307.
  • Anders HJ, Huber TB, Isermann B, Schiffer M. CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease. Nat Rev Nephrol. 2018Jun;14(6):361-377.
  • Yasuda-Yamahara M, Rogg M, Frimmel J, Trachte P, Helmstaedter M, Schroder P,Schiffer M, Schell C, Huber TB. FERMT2 links cortical actin structures, plasmamembrane tension and focal adhesion function to stabilize podocyte morphology.Matrix Biol. 2018 Aug;68-69:263-279
  • Schiffer M. Going single but not solo with podocytes: potentials, limitations,and pitfalls of single-cell analysis. Kidney Int. 2017 Nov;92(5):1038-1041.
  • Jacobs R, Langer-Jacobus T, Duong M, Stahl K, Haller H, Schmidt RE, Schiffer M. Detection and quantification of rituximab in the human urine. J Immunol Methods. 2017 Dec;451:118-121.
  • Duong M, Yu X, Teng B, Schroder P, Haller H, Eschenburg S, Schiffer M. Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes. J Biol Chem. 2017 Jul 21;292(29):12100-12110.
  • Müller-Deile J, Schiffer M. Podocytes from the diagnostic and therapeuticpoint of view. Pflugers Arch. 2017 Aug;469(7-8):1007-1015.
  • Müller-Deile J, Dannenberg J, Schroder P, Lin MH, Miner JH, Chen R, Bräsen JH,Thum T, Nyström J, Staggs LB, Haller H, Fiedler J, Lorenzen JM, Schiffer M. Podocytes regulate the glomerular basement membrane protein nephronectin by means of miR-378a-3p in glomerular diseases. Kidney Int. 2017 Oct;92(4):836-849.
  • Schenk H, Müller-Deile J, Schmitt R, Bräsen JH, Haller H, Schiffer M. Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb. J Clin Apher. 2017 Dec;32(6):444-452.
  • Schenk H, Müller-Deile J, Kinast M, Schiffer M. Disease modeling in genetic kidney diseases: zebrafish. Cell Tissue Res. 2017 Jul;369(1):127-141
  • Müller-Deile J, Teng B, Schenk H, Haller H, Reiser J, Sever S, Schiffer M. Drugs targeting dynamin can restore cytoskeleton and focal contact alterations of urinary podocytes derived from patients with nephrotic syndrome. Ann Transl Med. 2016 Nov;4(21):439.
  • Müller-Deile J, Gellrich F, Schenk H, Schroder P, Nyström J, Lorenzen J, Haller H, Schiffer M. Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans. Cell Physiol Biochem. 2016;40(5):819-830.
  • Korstanje R, Deutsch K, Bolanos-Palmieri P, Hanke N, Schroder P, Staggs L, Bräsen JH, Roberts IS, Sheehan S, Savage H, Haller H, Schiffer M. Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria. J Am Soc Nephrol. 2016 Nov;27(11):3271-3277.
  • Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M. CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes. 2016 Dec;65(12):3667-3679.
  • Müller-Deile J, Schiffer L, Hiss M, Haller H, Schiffer M. A new rescue regimen with plasma exchange and rituximab in high-risk membranous glomerulonephritis. Eur J Clin Invest. 2015 Dec;45(12):1260-9.
  • Hanke N, King BL, Vaske B, Haller H, Schiffer M. A Fluorescence-Based Assay for Proteinuria Screening in Larval Zebrafish (Danio rerio). Zebrafish. 2015 Oct;12(5):372-6.
  • Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park JK, Staggs L, Haller H, Erschow S, Hilfiker-Kleiner D, Wei C, Chen C, Tardi N, Hakroush S, Selig MK, Vasilyev A, Merscher S, Reiser J, Sever S. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015 Jun;21(6):601-9.
  • Müller-Deile J, Schiffer M. Podocyte directed therapy of nephroticsyndrome-can we bring the inside out? Pediatr Nephrol. 2016 Mar;31(3):393-405.doi: 10.1007/s00467-015-3116-4. Epub 2015 May 5. Review. PubMed PMID: 25939817.
  • Müller-Deile J, Schiffer M. The podocyte power-plant disaster and itscontribution to glomerulopathy. Front Endocrinol (Lausanne). 2014 Dec 15;5:209.
  • Sadowski CE, Lovric S, Ashraf S, Pabst WL, Gee HY, Kohl S, Engelmann S,Vega-Warner V, Fang H, Halbritter J, Somers MJ, Tan W, Shril S, Fessi I, LiftonRP, Bockenhauer D, El-Desoky S, Kari JA, Zenker M, Kemper MJ, Mueller D, Fathy HM, Soliman NA; SRNS Study Group, Hildebrandt F. A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 2015 Jun;26(6):1279-89.
  • Škoberne A, Behnert A, Teng B, Fritzler MJ, Schiffer L, Pajek J, Lindič J,Haller H, Schiffer M. Serum with phospholipase A2 receptor autoantibodiesinterferes with podocyte adhesion to collagen. Eur J Clin Invest. 2014 Aug;44(8):753-65.
  • Tossidou I, Himmelseher E, Teng B, Haller H, Schiffer M. SUMOylationdetermines turnover and localization of nephrin at the plasma membrane. Kidney Int. 2014 Dec;86(6):1161-73.
  • Behnert A, Schiffer M, Müller-Deile J, Beck LH Jr, Mahler M, Fritzler MJ.Antiphospholipase A₂ receptor autoantibodies: a comparison of three different immunoassays for the diagnosis of idiopathic membranous nephropathy. J Immunol Res. 2014;2014:143274
  • Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol. 2014 Sep;25(9):1991-2002.
  • Hanke N, Staggs L, Schroder P, Litteral J, Fleig S, Kaufeld J, Pauli C, Haller H, Schiffer M. "Zebrafishing" for novel genes relevant to the glomerular filtration barrier. Biomed Res Int. 2013;2013:658270
  • Worthmann K, Leitges M, Teng B, Sestu M, Tossidou I, Samson T, Haller H, Huber TB, Schiffer M. Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι. Am J Pathol. 2013 Dec;183(6):1945-1959
  • Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt K-U, Buchholz B. HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. Kidney Int 0, 2018.
  • Schenk LK, Buchholz B, Henke SF, Michgehl U, Daniel C, Amann K, Kunzelmann K, Pavenstädt HJ. Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria. Am. J. Physiol.-Ren. Physiol. (August 29, 2018). doi: 10.1152/ajprenal.00638.2017.
  • Burgmaier K, Kunzmann K, Ariceta G, Bergmann C, Buescher AK, Burgmaier M, Dursun I, Duzova A, Eid L, Erger F, Feldkoetter M, Galiano M, Geßner M, Goebel H, Gokce I, Haffner D, Hooman N, Hoppe B, Jankauskiene A, Klaus G, König J, Litwin M, Massella L, Mekahli D, Melek E, Mir S, Pape L, Prikhodina L, Ranchin B, Schild R, Seeman T, Sever L, Shroff R, Soliman NA, Stabouli S, Stanczyk M, Tabel Y, Taranta-Janusz K, Testa S, Thumfart J, Topaloglu R, Weber LT, Wicher D, Wühl E, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Zerres K, Ranguelov N, Godefroid N, Collard L, Lombet J, Maquet J, Schalk G, Querfeld U, Beck BB, Benzing T, Buettner R, Grundmann F, Kurschat C, Benz K, Tzschoppe A, Buchholz B, Buescher R, Häffner K, Pohl M, Gross O, Krügel J, Stock J, Patzer L, Oh J, Bernhardt W, Doyon A, Vinke T, Sander A, Henn M, Derichs U, Beetz R, Jeck N, Lange-Sperandio B, Ponsel S, Kusser F, Uetz B, Benz M, Schmidt S, Huppertz-Kessler C, Kranz B, Titieni A, Wurm D, Leichter HE, Bald M, Billing H, Nabhan MM, Lara LE, Papachristou F, Emma F, Cerkauskiene R, Azukaitis K, Wasilewska A, Balasz-Chmielewska I, Miklaszewska M, Tkaczyk M, Sikora P, Zaniew M, Niemirska A, Antoniewicz J, Lesiak J, Afonso AC, Teixeira A, Milosevski-Lomic G, Paripović D, Peco-Antic A, Papizh S, Bayazit AK, Anarat A, Soylu A, Kavukcu S, Candan C, Caliskan S, Canpolat N, Emre S, Alpay H, Akinci N, Conkar S, Poyrazoglu HM, Dusunsel R, Dötsch J, Schaefer F, Liebau MC. Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease. J Pediatr 199: 22–28.e6, 2018.
  • Ebner K, Schaefer F, Liebau MC, Consortium TAr, Eid LA, Ranguelov N, Adams B, van Hoeck K, Raes A, Mekahli D, Collard L, Lombet J, Maquet J, Cachat F, Schalk G, Seeman T, Ortiz Bruechle N, Zerres K, Thumfart J, Briese S, Querfeld U, Hoppe B, Feldkoetter M, Kirschstein M, Gruening G, Beck BB, Benzing T, Buettner R, Dötsch J, Goebel H, Grundmann F, Hero B, Kurschat C, Weber LT, Mayer B, Weber J, Ritter B, Benz K, Galiano M, Tzschoppe A, Buchholz B, Buescher R, Buescher A, Latta K, Häffner K, Pohl M, Gross O, Krügel J, Stock J, Patzer L, Teichler H, Oh J, Schild R, Illig T, Klopp N, Pape L, Wahrendorf S, Bernhardt W, Doyon A, Wuehl E, Vinke T, Sander A, Kunzmann K, Bergmann C, Wygoda S, Henn M, Wiemann D, Blaschke K, Derichs U, Beetz R, Jeck N, Klaus G, Fehrenbach H, Hampel T, Zoetler S, Wallot M, Kyrieleis H, Lange-Sperandio B, Ponsel S, Kusser F, Hoefele J, Uetz B, Benz M, Schmidt S, Huppertz-Kessler C, Kranz B, Koenig J, Titieni A, Boeswald M, Staude H, Jacoby U, Wurm D, Leichter HE, Bald M, Billing H, Gessner M, Beringer O, Ilmoja M-L, Soliman NA, Nabhan MM, Ariceta G, Lara LE, Garcia-Gonzalez MA, Diaz-Rodriguez C, Garcia-Vidal M, Ranchin B, Shroff R, Sterenborg R, Davitala T, Papachristou F, Stabouli S, Sallay P, Hooman N, Ardissino G, Testa S, Massella L, Emma F, Jankauskiene A, Cerkauskiene R, Azukaitis K, Bokenkamp A, van Wijk J, Taranta-Janusz K, Wasilewska A, Zagozdzon I, Balasz-Chmielewska I, Miklaszewska M, Zachwieja K, Drozdz D, Tkaczyk M, Stanczyk M, Sikora P, Zaniew M, Litwin M, Niemirska A, Wicher D, Jankowska I, Antoniewicz J, Lesiak J, Lipinski P, Szczepanska M, Adamczyk P, Morawiec-Knysak A, Caldas Afonso A, Teixeira A, Milosevski-Lomic G, Paripović D, Peco-Antic A, Prikhodina L, Papizh S, Bayazit AK, Anarat A, Melek E, Bayrakci US, Kantar A, Cayci S, Baskin UE, Duzova A, Yuzbasioglu A, Soylu A, Kavukcu S, Kalman S, Evrengül H, Yüksel S, Kara A, Gurgoze MK, Candan C, Sever L, Caliskan S, Canpolat N, Emre S, Yilmaz A, Gökce I, Alpay H, Akinci N, Mir S, Sozeri B, Dursun I, Poyrazoglu HM, Dusunsel R, Nalcacioglu H, Ekinci Z, Tabel Y, Delibas A, Övünc Hacihamdioglu D, Guay-Woodford L, Study GE, Study GG. Recent Progress of the ARegPKD Registry Study on Autosomal Recessive Polycystic Kidney Disease. Front Pediatr 5, 2017.
  • Schellinger IN, Cordasic N, Panesar J, Buchholz B, Jacobi J, Hartner A, Klanke B, Jakubiczka-Smorag J, Burzlaff N, Heinze E, Warnecke C, Raaz U, Willam C, Tsao PS, Eckardt K-U, Amann K, Hilgers KF. Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int 91: 616–627, 2017.
  • Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schodel J, Eckardt KU, Buchholz B. P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal 12: 687–695, 2016.
  • Buchholz B, Schley G, Eckardt KU. The impact of hypoxia on nephrogenesis. Curr Opin Nephrol Hypertens 25: 180–6, 2016.
  • Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B. Glucose promotes secretion-dependent renal cyst growth. J Mol Med Berl 94: 107–17, 2016.
  • Schley G, Scholz H, Kraus A, Hackenbeck T, Klanke B, Willam C, Wiesener MS, Heinze E, Burzlaff N, Eckardt KU, Buchholz B. Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis. Kidney Int 88: 1283–1292, 2015.
  • Forschbach V, Goppelt-Struebe M, Kunzelmann K, Schreiber R, Piedagnel R, Kraus A, Eckardt KU, Buchholz B. Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation. Cell Death Dis 6: e1899, 2015.
  • Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU. Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion. J Am Soc Nephrol 25: 465–74, 2014.
  • Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K. Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int 85: 1058–67, 2014.
  • Boehlke C, Kotsis F, Buchholz B, Powelske C, Eckardt K, Walz G, Nitschke R, Kuehn EW. Kif3a Guides Microtubular Dynamics, Migration and Lumen Formation of MDCK Cells. PLoS One 8: e62165, 2013.
  • K.U. Eckardt, M. Wiesener. „Autosomal dominante tubulointerstitielle Nierenerkrankungen (ADTKD)“. Der Nephrologe 2015; 10:379–381.
  • B. Hohenstein, C. Licht, M. Wiesener, K. Amann, F. Schaefer, C. Serka, C. Bergmann, M. Kirschfink, P. Zipfel, C. Hugo. “State-of-the-art: C3-Glomerulopathie und membranoproliferative Glomerulonephritis“. Der Nephrologe, 2015/4.
  • Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF. “Complement factor H-related hybrid protein deregulates complement in dense deposit disease.“ J Clin Invest. 2014 Jan 2;124(1):145-55.
  • Ekici AB, Hackenbeck T, Morinière V, Pannes A, Buettner M, Uebe S, Janka R, Wiesener A, Hermann I, Grupp S, Hornberger M, Huber TB, Isbel N, Mangos G, McGinn S, Soreth-Rieke D, Beck BB, Uder M, Amann K, Antignac C, Reis A, Eckardt KU, Wiesener MS. “Renal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulin.“ Kidney Int. 2014 Sep;86(3):589-99.
  • Eckardt KU, Alper SL, Antignac C, Bleyer AJ, Chauveau D, Dahan K, Deltas C, Hosking A, Kmoch S, Rampoldi L, Wiesener M, Wolf MT, Devuyst O. “Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management-A KDIGO consensus report.“ Kidney Int. 2015 Mar 4. doi: 10.1038/ki.2015.28.
  • Jobst-Schwan T, Pannes A, Schlingmann KP, Eckardt KU, Beck BB, Wiesener MS. “Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis.” Kidney Blood Press Res. 2015;40(5):443-51. doi: 10.1159/000368520. Epub 2015 Aug 22.
  • Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF. “Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.“ J Am Soc Nephrol. 2015 Oct 2. pii: ASN.2015020212.
  • Wehling C, Amon O, Bommer M, Hoppe B, Kentouche K, Schalk G, Weimer R, Wiesener M, Hohenstein B, Tönshoff B, Büscher R, Fehrenbach H, Gök ÖN, Kirschfink M. “Monitoring of complement activation biomarkers and eculizumab in complement-mediated renal disorders.“ Clin Exp Immunol. 2017 Feb;187(2):304-315.
  • Connor, TM, Hoer S, Mallett A, Gale DP, Gomez-Duran A, Posse V, Antrobus R, Moreno P, Sciacovelli M, Frezza C, Duff J, Sheerin NS, Sayer JA, Ashcroft M, Wiesener MS, Hudson G, Gustafsson CM, Chinnery PF, Maxwell PH. “Mutations in mitochondrial DNA causing tubulointerstitial kidney disease“. PLoS Genetics, 2017 Mar 7;13(3):e1006620.
  • Wenzel A, Altmueller J, Ekici AB, Popp B, Stueber K, Thiele H, Pannes A, Staubach S, Salido E, Nuernberg P, Reinhardt R, Reis A, Rump P, Hanisch FG, Wolf MTF, Wiesener M, Huettel B, Beck BB. “Single molecule real time sequencing in ADTKD-MUC1 allows complete assembly of the mutational hotspot and exact positioning of causative mutations within the VNTR.” Sci Rep. 2018 Mar 8;8(1):4170.
  • Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF. “FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.” J Immunol. 2018 Apr 1;200(7):2280-2290.
  • Knaup KX, Hackenbeck T, Popp B, Stoeckert J, Wenzel A, Büttner-Herold M, Pfister F, Schueler M, Seven D, May AM, Halbritter J, Gröne H-J, Reis A, Beck BB, Amann K, Ekici AB, Wiesener MS. “Biallelic Expression of Mucin-1 in Autosomal Dominant Tubulointerstitial Kidney Disease: Implications for Nongenetic Disease Recognition.“ J Am Soc Nephrol. 2018 Sep;29(9):2298-2309. doi: 10.1681/ASN.2018030245. Epub 2018 Jul 26.
  • Choudhry H*, Schodel J*, Oikonomopoulos S, Camps C, Grampp S, Harris AL, Ratcliffe PJ, Ragoussis J, and Mole DR. Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. EMBO Rep 15: 70-76, 2014. *joined first authorship.
  • Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt JL, Smythies J, Choudhry H, Goppelt-Struebe M, Ratcliffe PJ, Mole DR, and Schodel J. Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet 13: e1006872, 2017.
  • Grampp S, Platt JL, Lauer V, Salama R, Kranz F, Neumann VK, Wach S, Stohr C, Hartmann A, Eckardt KU, Ratcliffe PJ, Mole DR, and Schodel J. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nat Commun 7: 13183, 2016.
  • Berner D, Zenkel M, Pasutto F, Hoja U, Liravi P, Gusek-Schneider GC, Kruse FE, Schodel J, Reis A, and Schlotzer-Schrehardt U. Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response. Invest Ophthalmol Vis Sci 58: 5930-5940, 2017.
  • Pasutto F, Zenkel M, Hoja U, Berner D, Uebe S, Ferrazzi F, Schodel J, Liravi P, Ozaki M, Paoli D, Frezzotti P, Mizoguchi T, Nakano S, Kubota T, Manabe S, Salvi E, Manunta P, Cusi D, Gieger C, Wichmann HE, Aung T, Khor CC, Kruse FE, Reis A, and Schlotzer-Schrehardt U. Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1. Nat Commun 8: 15466, 2017.
  • Chan MC, Ilott NE, Schodel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, and Schofield CJ. Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases. J Biol Chem 291: 20661-20673, 2016.
  • Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schodel J, Eckardt KU, and Buchholz B. P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic signalling 12: 687-695, 2016.
  • Siegert I, Schodel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, and Jantsch J. Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1alpha upon LPS Activation in the Presence of Ample Oxygen. Cell reports 13: 2048-2055, 2015.
  • Schorg A, Santambrogio S, Platt JL, Schodel J, Lindenmeyer MT, Cohen CD, Schrodter K, Mole DR, Wenger RH, and Hoogewijs D. Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping. Nucleic Acids Res 43: 5810-5823, 2015.
  • Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, Schodel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, and Mole DR. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2alpha dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene 34: 4546, 2015.
  • Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Munzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schodel J, McCullagh JSO, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, and Coleman ML. Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1. Molecular Cell 53: 645-654, 2014.
  • McCormick RI, Blick C, Ragoussis J, Schoedel J, Mole DR, Young AC, Selby PJ, Banks RE, and Harris AL. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. Br J Cancer 108: 1133-1142, 2013.
  • Schodel J, Grampp S, Maher ER, Moch H, Ratcliffe PJ, Russo P, and Mole DR. Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer. Eur Urol 69: 646-657, 2016.
  • Jantsch J and Schodel J. Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology 220: 305-314, 2015.
  • Schodel J, Mole DR, and Ratcliffe PJ. Pan-genomic binding of hypoxia-inducible transcription factors. Biol Chem 394: 507-517, 2013.
  • Lauer V and Schodel J. Hypoxia-inducible Factor Crosses the Checkpoint. Eur Urol 70: 633-634, 2016.
  • Schodel J, Mole DR: Mapping the HIF Transcription Factor in Cancer by ChIP-Seq Technology; pp 91-117; in Next Generation Sequencing in Cancer Research; Volume 1: Decoding the Cancer Genome; Wu, Wei: Choudhry, Hani (Eds.) Springer, 2013.
  • Kopp C, Linz P, Maier C, Wabel P, Hammon M, Nagel AM, Rosenhauer D, Horn S, Uder M, Luft FC, Titze J and Dahlmann A. Elevated tissue Na+ deposition in type 2 diabetic hemodialysis patients detected by 23Na-Magnetic Resonance Imaging. Kidney Int. 2018 May;93(5):1191-1197
  • Benz K, Schlote J, Daniel C, Kopp C, Dahlmann A, Schröder A, Cordasic N, Klanke B, Hilgers KF, Titze J, Amann K. Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention. Kidney Blood Press Res. 2018;43(1):1-11
  • Schneider MP, Hilgers KF, Schmid M, Hübner S, Nadal J, Seitz D, Busch M, Haller H, Köttgen A, Kronenberg F, Baid-Agrawal S, Schlieper G, Schultheiss U, Sitter T, Sommerer C, Titze S, Meiselbach H, Wanner C, Eckardt KU; GCKD Study Investigators. Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS One. 2018 Aug 20;13(8):e0202604
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  • Schneider MP, Hilgers KF. Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralo-corticoid Receptor Antagonism? Hypertension 2017 Jan;69(1):11-12
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  • Nesterov V, Krueger B, Bertog M, Dahlmann A, Palmisano R, Korbmacher C. In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal Nephron. Hypertension.2016 Jun;67(6):1256-62
  • Mansley MK, Neuhuber W, Korbmacher C, Bertog M. Norepinephrine stimulates the epithelial Na+ channel in cortical collecting duct cells via α2-adrenoceptors. Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F450-8
  • Rauh R, Soell D, Haerteis S, Diakov A, Nesterov V, Krueger B, Sticht H, Korbmacher C. A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L43-55
  • Kopp C, Linz P, Dahlmann A, Hammon M, Jantsch J, Müller DN, Schmieder RE, Cavallaro A, Eckardt KU, Uder M, Luft FC, Titze J. 23Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients. Hypertension 2013; 61(3): 635-40.
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